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Figure 1. Diagram of PHM mutants studied. Rat DProPHM-382s is drawn to scale; the 10 amino acid proregion following the signal sequence was deleted. Rat PAM-1(53-343) is homologous to rat DbM(208-514); Cys residues conserved between PHM and DbM are indicated (McMahon et al., 1990; Stoffers et al., 1989). COOH-terminal truncations and residues altered by site-directed mutagenesis are indicated. The reactions catalyzed by PHM and DBM are shown.

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